In the microbiology industry, penicillin and other antibiotics are very impressive. The annual production of penicillin is approximately 33,000 metric tons, with a market share of over $ 400 million [8]. Annual sales of raw materials on a global scale from four Group Top of penicillin antibiotics, cephalosporin [1], tetracycline [2] and erythromycin [3], 2.4 billion dollars in America have been reported.

Introduction to Chemical Engineering

In the early 1940s by Alexander Fleming isolated the fungus Penicillium Nvtatvm [4], respectively. He observed the cellular components autolysis medium Staphylococcus aureus [5] themselves from ruin. Today, penicillin is produced with better mildew components. The development of submerged culture media, which is a mushroom in aqueous solution, increases the cultivation of large-scale mushrooms through the application of sterilized air.

• Streptomycin [6] produced by actinomycetes [7]
• Molasses, corn syrup, sugar industry remnants, and wet corn mills are used to produce penicillin.
• Penny Sylyvm Krysvjnyvm [8] can produce 100 times more than the medium Fleming.

Recombinant DNA technology

The main steps in the production of penicillin are:

• Inoculum preparation
• Prepare and sterilize the environment
• Intrauterine insemination
• Compulsory aeration with sterilized air during incubation
• Remove the growth of mold and fungus after fermentation
• Extraction and purification of penicillin

[1] Cephalosporin

[2] Tetracycline

[3] Erythromycin

[4] Penicillium notatum

[5] Staphylococcus aureus

[6] Streptomycin

[7] Actinomycetes

[8] Penicillium chrysogenum

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