Production of penicillin antibiotics

Production of penicillin antibiotics

penicillin antibiotics

In the microbiology industry, penicillin and other antibiotics are very impressive. The annual production of penicillin is approximately 33,000 metric tons, with a market share of over $ 400 million [8]. Annual sales of raw materials on a global scale from four Group Top of penicillin antibiotics, cephalosporin [1], tetracycline [2] and erythromycin [3], 2.4 billion dollars in America have been reported.

Introduction to Chemical Engineering

In the early 1940s by Alexander Fleming isolated the fungus Penicillium Nvtatvm [4], respectively. He observed the cellular components autolysis medium Staphylococcus aureus [5] themselves from ruin. Today, penicillin is produced with better mildew components. The development of submerged culture media, which is a mushroom in aqueous solution, increases the cultivation of large-scale mushrooms through the application of sterilized air.

  • Streptomycin [6] produced by actinomycetes [7]
  • Molasses, corn syrup, sugar industry remnants, and wet corn mills are used to produce penicillin.
  • Penny Sylyvm Krysvjnyvm [8] can produce 100 times more than the medium Fleming.

Recombinant DNA technology

The main steps in the production of penicillin are:

  • Inoculum preparation
  • Prepare and sterilize the environment
  • Intrauterine insemination
  • Compulsory aeration with sterilized air during incubation
  • Remove the growth of mold and fungus after fermentation
  • Extraction and purification of penicillin

[1] Cephalosporin

[2] Tetracycline

[3] Erythromycin

[4] Penicillium notatum

[5] Staphylococcus aureus

[6] Streptomycin

[7] Actinomycetes

[8] Penicillium chrysogenum

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